Journal of Scientific and Technical Research
Issue 2, 2019
Original Articles
Abstract
This paper presented binding interaction of 3-(Furan-2-yl)-N-phenylprop-2-enamide (3FNPP2M) with bovine serum albumin (BSA) by equilibrium dialysis and FT-IR spectroscopy at physiological pH in various solvents. Findings were interpreted by scatchard plot in terms of association constants. The increased in association constants with increase in concentrations of the 3FNPP2M is observed. The binding interaction is found to be more in 1, 4-dioxane than DMSO and DMF.FT-IR study explained the binding interaction through shift in peak positions of amide I and II bands. FT-IR study confirmed the binding of 3FNPP2M with BSA in terms of changes in secondary structure of BSA. In this study, we have also reported the effect of foreign particles viz. arsenic and mercury on the binding interaction of 3FNPP2M with BSA. Reactivity and association of 3FNPP2M with BSA in presence of foreign moieties were calculated and compared
This paper presented binding interaction of 3-(Furan-2-yl)-N-phenylprop-2-enamide (3FNPP2M) with bovine serum albumin (BSA) by equilibrium dialysis and FT-IR spectroscopy at physiological pH in various solvents. Findings were interpreted by scatchard plot in terms of association constants. The increased in association constants with increase in concentrations of the 3FNPP2M is observed. The binding interaction is found to be more in 1, 4-dioxane than DMSO and DMF.FT-IR study explained the binding interaction through shift in peak positions of amide I and II bands. FT-IR study confirmed the binding of 3FNPP2M with BSA in terms of changes in secondary structure of BSA. In this study, we have also reported the effect of foreign particles viz. arsenic and mercury on the binding interaction of 3FNPP2M with BSA. Reactivity and association of 3FNPP2M with BSA in presence of foreign moieties were calculated and compared
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Abstract
The Baker-Venkataramn transformation using NaOH in dimethylsulphoxide (DMSO) 77 have been employed for the coversions of ester (o-aroyloxy/ heteroaroyloxyacetophenones) into the corresponding bis β-diketones. A novel class of 2, 8-bis(aryl/heteroaryl) pyrano [3, 2- γ] chromene-4, 6-diones have been synthesized. Bis- β diketones obtained undergoes cyclisation to achieve 2, 8-bis(aryl/heteroaryl) pyrano [3, 2- γ] chromene-4, 6-diones with impressive yields. Reaction mechanism for their formation have been elucidated. 4, 6- Diacetylresorcinol was obtained by the acylation of resorcinol. The structures of these compounds were confirmed by IR, NMR and Mass spectral studies
The Baker-Venkataramn transformation using NaOH in dimethylsulphoxide (DMSO) 77 have been employed for the coversions of ester (o-aroyloxy/ heteroaroyloxyacetophenones) into the corresponding bis β-diketones. A novel class of 2, 8-bis(aryl/heteroaryl) pyrano [3, 2- γ] chromene-4, 6-diones have been synthesized. Bis- β diketones obtained undergoes cyclisation to achieve 2, 8-bis(aryl/heteroaryl) pyrano [3, 2- γ] chromene-4, 6-diones with impressive yields. Reaction mechanism for their formation have been elucidated. 4, 6- Diacetylresorcinol was obtained by the acylation of resorcinol. The structures of these compounds were confirmed by IR, NMR and Mass spectral studies
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Abstract
Chrysomya megacephala (Diptera: Calliphoridae) also known as oriental latrine fly is blow fly species widely distributed in many parts of the world. This fly has forensic importance as it infests on carrion soon after death and helps not only to estimate the post-mortem interval (PMI) but also to detect poisoning in a putrefying body. The present study was carried out on morphological identification of Chrysomya megacephala using key Lutz, 2018 and Cytochrome C Oxidase (COI). The special attention was focused on the tertiary morphological characteristics of flies collected from Nagpur region. The new COI subunit I (588 bp) gene sequence of Chrysomya megacephala have been added to GenBank (Accession No.- MN082633).
Chrysomya megacephala (Diptera: Calliphoridae) also known as oriental latrine fly is blow fly species widely distributed in many parts of the world. This fly has forensic importance as it infests on carrion soon after death and helps not only to estimate the post-mortem interval (PMI) but also to detect poisoning in a putrefying body. The present study was carried out on morphological identification of Chrysomya megacephala using key Lutz, 2018 and Cytochrome C Oxidase (COI). The special attention was focused on the tertiary morphological characteristics of flies collected from Nagpur region. The new COI subunit I (588 bp) gene sequence of Chrysomya megacephala have been added to GenBank (Accession No.- MN082633).
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Abstract
Plant is an important source of medicine and plays a key role in human health. Medicinal plants having both antiglycation and antioxidant activity can be of good therapeutic value in reducing complications of diabetes and slowing down aging process. Advanced Glycation End product (AGE’S) formation is due to nonenzymatic glycation and oxidative stress, which has been demonstrated in the pathogenesis of diabetic complication and aging processes. In this study we have investigated the antiglycation effect of Cynodon dactylon and Cympobogon citratus plants which are being used in the treatment of diabetes mellitus. Results indicated that the concentration of the Cympobogon citratus extract increases and the absorbance decreases from 0.027 ± 0.011 and reaches minimum 0.012 ± 0.0011 at 390 μg/ml. The same trend is observed with Cynodon dactylon extract too which reaches its minimum of 0.006 ± 0.0028 at concentration of 390 μg/ml from maximum absorbance of 0.024 ± 0.006. Antiglycation activity of Cympobogan citratus is more as compared to Cynodan dactylon. The result also show that precent inhibition of glycation reaction by Cympobogon citratus is lower than Cynodon dactylon.
Plant is an important source of medicine and plays a key role in human health. Medicinal plants having both antiglycation and antioxidant activity can be of good therapeutic value in reducing complications of diabetes and slowing down aging process. Advanced Glycation End product (AGE’S) formation is due to nonenzymatic glycation and oxidative stress, which has been demonstrated in the pathogenesis of diabetic complication and aging processes. In this study we have investigated the antiglycation effect of Cynodon dactylon and Cympobogon citratus plants which are being used in the treatment of diabetes mellitus. Results indicated that the concentration of the Cympobogon citratus extract increases and the absorbance decreases from 0.027 ± 0.011 and reaches minimum 0.012 ± 0.0011 at 390 μg/ml. The same trend is observed with Cynodon dactylon extract too which reaches its minimum of 0.006 ± 0.0028 at concentration of 390 μg/ml from maximum absorbance of 0.024 ± 0.006. Antiglycation activity of Cympobogan citratus is more as compared to Cynodan dactylon. The result also show that precent inhibition of glycation reaction by Cympobogon citratus is lower than Cynodon dactylon.
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