Orofacial pain is one of the most widespread and debilitating diseases condition affecting the head, face, and temporomandibular joint (TMJ), as well as other tissues. It can arise from different aetiologies and occur in different regions. In contrast to neurovascular disorders like primary headache, which can manifest as persistent orofacial pain, trigeminal neuropathic problems are caused by damage from dental treatments, infections, neoplasms, or malfunction of the Peripheral or central nervous system. The sufferers’ quality of life is impacted by all these trigeminal system disorders. When choosing a treatment plan for orofacial pain problems, a multidisciplinary strategy that uses both non-pharmacological and pharmacological way should be considered.